Toward Specific Detection of Peroxynitrite─Intramolecular Cyclization of Boronobenzylated Pyridinium Probe in Chemical and Cellular Systems.

ABSTRACT: Detecting and quantifying peroxynitrite (ONOO^-) under physiological conditions is challenging due to its low steady-state levels, resulting from typically low fluxes of nitric oxide (^•NO) and superoxide (O₂^•-), as well as its short half-life caused by rapid reactions with cellular and extracellular targets. Low-molecular-weight boronate probes that react rapidly with ONOO^- to form stable and characteristic products represent the most promising class of redox probes for ONOO^- detection and quantitative analyses in chemical and biological systems. Because boronates also respond to other nucleophilic oxidants, including hydrogen peroxide (H₂O₂), novel approaches to selectively detect ONOO^- are n

SUBMITTER: Grzelakowska A 

PROVIDER: S-EPMC12820976 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature