Mechanically gated currents in mouse sensory neurons lacking PIEZO2.

ABSTRACT: Touch sensation starts with the opening of mechanically gated activated ion channels at neuroglial endings of mechanoreceptors in the skin. The function of around half of low-threshold mechanoreceptors is dependent on the presence of the mechanically gated ion channel PIEZO2. It has been reported that particularly rapidly adapting mechanosensitive currents (RA currents) in the cell bodies of acutely cultured sensory neurons are dependent on PIEZO2. Here we re-examined this question by making a quantitative study of mechanically gated currents activated by substrate deflection in sensory neurons lacking PIEZO2. We characterized mechanically gated currents from embryonic and postnatal sensory neurons, taken from global Piezo2^-/- or Piezo2 conditional knockouts (Piezo2^cKO

SUBMITTER: Sanchez-Carranza O 

PROVIDER: S-EPMC12820996 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature