Measurement force, speed, and postmortem time affect the ratio of CNS gray-to-white-matter elasticity.

ABSTRACT: For several decades, many attempts have been made to characterize the mechanical properties of gray and white matter, which constitute the two main compartments of the central nervous system, with various methods and contradictory results. In particular, the ratio of gray-to-white-matter elasticity is sometimes larger than 1 and sometimes smaller; the reason for this apparent discrepancy is currently unknown. Here, we exploited atomic force microscopy-based indentation measurements to systematically investigate how the measurement force, measurement speed, postmortem interval, and temperature affect the measured elasticity of spinal cord tissue and, in particular, the ratio of gray-to-white-matter elasticity (K_g/K_w). Within the explored parameter space, increasing mea

SUBMITTER: Becker JM 

PROVIDER: S-EPMC12821018 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature