Tracking the morphological evolution of neuronal dendrites by first-passage analysis.

ABSTRACT: A high degree of structural complexity arises in dynamic neuronal dendrites due to extensive branching patterns and diverse spine morphologies, which enable the nervous system to adjust function, construct complex input pathways, and thereby enhance the computational power of the system. Recognition of pathological changes due to neurodegenerative disorders is of crucial importance due to the determinant role of dendrite morphology in the functionality of the nervous system. Nevertheless, direct noninvasive measurements to collect adequate structural data in a reasonable time are currently not feasible. Here, we present a stochastic coarse-grained framework based on first-passage analysis to infer key dendritic morphological features affected by neurodegenerative diseases-including the den

SUBMITTER: Kreten FH 

PROVIDER: S-EPMC12821030 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature