Development of a smartphone-based app to support the differential diagnosis in patients with primary left ventricular hypertrophy.

ABSTRACT:

Aims

Patients with primary left ventricular hypertrophy (LVH) often experience a diagnostic delay of several years, largely related to fragmented knowledge among different specialties and the rarity of the conditions. We developed and validated a digital support tool to guide the physician in the differential diagnostic process of patients presenting with primary LVH.

Methods and results

A total of 818 patients with definitive diagnosis of sarcomeric hypertrophic cardiomyopathy (HCM) or one of its phenocopies [479 (62%) males, 48 ± 24 years] were included. Pre-specified disease-specific red flags (RFs) were categorized into five domains: family history, signs/symptoms, electrocardiography, echocardiographic, and laboratory. Each patient's characteristics were inserted by two

SUBMITTER: Maurizi N 

PROVIDER: S-EPMC12821060 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature