Facile one-pot construction of copper-loaded polydopamine films on NiTi alloy for adjustable antibacterial activity and enhanced corrosion resistance.

ABSTRACT: Nickel-titanium (NiTi) alloys are widely employed as implantable devices, but their intrinsic poor antibacterial activity and Ni-ion release remain a major challenge. Leveraging copper's antibacterial efficacy, we developed a facile one-pot route to construct copper-loaded polydopamine films on NiTi alloy (Cu@PDA/NiTi). In a dopamine-CuSO₄ mixture, dopamine simultaneously polymerizes and reduces Cu²⁺, the resulting Cu²⁺ coordinates with PDA to form a metal-phenolic network (MPN), which incorporates both Cu²⁺ and Cu nanoparticles (NPs). By tuning CuSO₄ concentration (C _CuSO4 ) from 1 to 30 mM, the Cu@PDA/NiTi possesses adjustable Cu content and antibacterial potency. Antibacterial ratios toward Escherichi

SUBMITTER: Li Y 

PROVIDER: S-EPMC12821150 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature