Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: multicentre, randomised clinical trial.

ABSTRACT:

Objective

To test the hypothesis that women assigned to a natural ovulation regimen before frozen embryo transfer compared with a programmed regimen would have an increased chance of a healthy live birth and a reduced risk of pre-eclampsia or eclampsia.

Design

Multicentre, randomised, parallel group, assessor blinded clinical trial.

Setting

24 academic fertility centres in China.

Participants

4376 ovulatory women (aged 20-40 years) planning to undergo a frozen single blastocyst transfer.

Interventions

Eligible participants were randomised (1:1) to receive a natural ovulation regimen or a programmed regimen of hormone replacement for endometrial preparation. Endometrial preparation and frozen embryo transfer timing were determined in the natural ovulation

SUBMITTER: Wei D 

PROVIDER: S-EPMC12821156 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature