Long term use of proton pump inhibitors and risk of stomach cancer: population based case-control study in five Nordic countries.

ABSTRACT:

Objective

To help to clarify whether long term use of proton pump inhibitors is associated with an increased risk of gastric adenocarcinoma by designing a study that considered the existing literature's methodological weaknesses.

Design

Population based case-control study using prospectively collected data from multiple complete nationwide registries in five Nordic nations.

Setting

All healthcare in five Nordic countries-Denmark, Finland, Iceland, Norway, and Sweden-between 1994 and 2000.

Participants

Case patients with gastric adenocarcinoma, each matched for age, sex, calendar year, and country with 10 control participants randomly identified from each country's entire population.

Exposure

The exposure was long term (>1 year) proton pump inhibitor use,

SUBMITTER: Duru O 

PROVIDER: S-EPMC12821158 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature