Effects of inactivated COVID-19 vaccination on HIV viremia and reservoir size: a longitudinal cohort study.

ABSTRACT:

Background

Vaccination is regarded as the most effective and cost-efficient mean of managing COVID-19. Whether receiving inactivated vaccine leads to plasma viral load (pVL) rebound and affects HIV reservoirs size has been a major concern for people living with HIV (PLWH). In this study we performed a longitudinal observational study to explore the dynamic changes of pVL and HIV-1 total DNA with PLWH after vaccination with inactivated COVID-19 vaccine.

Methods

Information and venous blood samples from PLWH were collected prevaccination (BC1), three weeks after the first vaccination (BC2), four weeks after the second dose (BC3), six months after the second dose (BC4), and two weeks after the third dose (BC5) to test RBD-specific IgG antibody, plasma viral load (pVL), HIV-1 to

SUBMITTER: Li J 

PROVIDER: S-EPMC12821177 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature