Organic-Inorganic Hybrid Nanofiber Membranes by Electrospinning: Engineering Features and Cytocompatibility.

ABSTRACT: Organic-inorganic (O/I) hybrid fibrous scaffolds represent a cutting-edge attempt for replicating the extracellular matrix (ECM) in tissue engineering. This study introduces an O/I hybrid composed of borosilicate-calcium elements incorporated with poly-(ε-caprolactone) (PCL) using an eco-friendly, in situ sol-gel process. The purpose of this research was to electrospin this hybrid composition into nanofibrous mats and investigate the impact of the electrospinning parameters on membrane properties. Critical electrospinning parameters (distance, flow rate, and voltage) were optimized to refine spinning behavior and assess their influence on fiber's morphology and diameter, being optimal conditions were achieved with a distance of 12 cm, a flow rate between 125 and 150 μL·h^-1

SUBMITTER: Coelho SAR 

PROVIDER: S-EPMC12821186 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature