Site-specific noninvasive delivery of retrograde viral vectors to the brain.

ABSTRACT: Neuronal activity underlies the brain function. Different behaviors, physiological processes, and disorders depend on which neurons are active at a given moment. Treating brain disorders without side effects will require exclusive control of disease-relevant neurons. Traditionally, small molecule drugs could control a subset of neurons that express a molecularly specific receptor. Local noninvasive therapies such as delivery of neuromodulatory agents with focused ultrasound blood-brain barrier opening (FUS-BBBO) also added spatial precision, allowing one to control specific brain regions without surgery. However, the final characteristic of neurons, which other neurons they connect to, remains underexplored as a therapeutic target. If targeting neurons based on their connectivity was possi

SUBMITTER: Harb M 

PROVIDER: S-EPMC12821222 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature