The impact of early pregnancy uric acid on gestational diabetes risk: a prospective cohort study in Northwest China.

ABSTRACT:

Background

Elevated uric acid (UA) has become a global health concern. We aimed to investigate the impact of UA in women during early pregnancy on the subsequent risk of gestational diabetes mellitus (GDM).

Methods

Pregnant women in their first trimester were recruited from a birth cohort study conducted in Xi'an, China, between July 2018 and December 2023. A generalized linear model (GLM) was used to calculate risk ratios (RRs) and 95% confidence intervals (CIs) for the effects of UA levels.

Results

Compared with the first quartile of UA, the second (RR = 1.15, 95% CI = 1.04-1.28), third (RR = 1.27, 95% CI = 1.15-1.41), and fourth (RR = 1.46, 95% CI = 1.32-1.61) quartiles were associated with an increased risk of GDM. Moreover, UA was the strongest predictor among al

SUBMITTER: Zhao D 

PROVIDER: S-EPMC12821261 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature