Could the estrobolome have a role in endometriosis pathogenesis and infertility? A systematic review.

ABSTRACT:

Background

Endometriosis is a chronic, estrogen-dependent condition affecting 10% of reproductive-aged women, often associated with infertility and chronic pelvic pain. Recent evidence suggests that gut microbiota dysbiosis and alterations in the estrobolome, defined as the collection of bacterial genes involved in estrogen metabolism, may play a role in the pathogenesis of endometriosis and infertility.

Methods

This systematic review was registered with PROSPERO (ID: CRD42024627464). A comprehensive search was conducted across PubMed, Embase, Scopus, Web of Science, Cochrane CENTRAL, ClinicalTrials.gov, and grey literature sources up to December 2024, without a lower date limit. The search included terms such as "estrobolome," "endometriosis," "infertility," and "estrogen m

SUBMITTER: Saponara S 

PROVIDER: S-EPMC12821278 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature