Viral diversity influences T-cell responses to enteric human adenoviruses F40 and F41.

ABSTRACT:

Background

Human enteric species F adenoviruses are a leading cause of diarrhoea-associated paediatric morbidity and mortality worldwide. The cellular immune response (antigen-specific cytotoxic T cells and secreted cytokines) to human adenovirus (HAdV) infection is known to ameliorate symptoms and is critical for viral clearance. We hypothesized that the capsid proteins (hexon and penton) of HAdV-F40 and 41 (F40, F41) are evolving to escape cellular immune responses. Major histocompatibility complex (MHC) binding of viral peptides is a key step in the presentation of peptide-MHC complexes which activate the T-cell receptor and the cytotoxic T-cell response.

Methods

Using global HAdV genomic data, we predicted MHC-peptide binding within the hexon and penton proteins of F40 a

SUBMITTER: Craven HM 

PROVIDER: S-EPMC12821363 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature