Hypoxia Increases Cardiac Proteasomal Activity and Differentially Modulates Cullin-RING E3 Ligases in the Naked Mole-Rat <i>Heterocephalus glaber</i>.

ABSTRACT: (1) Background: The naked mole-rat (Heterocephalus glaber) survives hypoxia-reoxygenation stresses by utilizing metabolic rate depression, achieved in part by downregulating nonessential genes and processes to conserve endogenous cellular resources and prevent buildup of toxic waste byproducts. Tight molecular control of protein degradation (specifically the ubiquitin-proteasome system) is a potent regulatory tool for maintaining muscle integrity during hypoxia, but how this system is regulated in the heart of hypoxia-tolerant species is poorly understood. (2) Methods: The protein expression levels of cullin-RING E3 ligases (specifically CRL4 architecture), deubiquitinating enzymes, and proteasomal activity were assayed in cardiac tissues from H. glaber exposed to 24 h of nor

SUBMITTER: Ingelson-Filpula WA 

PROVIDER: S-EPMC12821419 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature