Adverse Drug Reaction to Linezolid in Drug-Resistant Tuberculosis: A Systematic Review.

ABSTRACT: Background/Objectives: The use of linezolid in drug-resistant tuberculosis has shown good effectiveness but has a high risk of adverse drug reactions (ADRs). Linezolid-related ADRs have been widely reported and may affect their therapeutic effect. This systematic review aimed to describe linezolid-related ADRs in drug-resistant tuberculosis. Methods: This literature review was conducted on PubMed, Scopus, ProQuest, and Sage without year limitation, up to June 2023. Study quality was assessed using the JBI checklist to evaluate method quality and risk of bias in the included articles. Inclusion criteria included studies assessing linezolid-correlated ADRs in drug-resistant tuberculosis patients with individual regimens, having access to the full text, and using the English or

SUBMITTER: Oktaviani E 

PROVIDER: S-EPMC12821610 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature