Treatment Adherence and Persistence of Anti-Fibrotic Drugs in Real Life in Greece.

ABSTRACT:

Background

Nintedanib and pirfenidone are two anti-fibrotic agents for diseases within the interstitial lung diseases (ILDs) spectrum. Here, we provide a comprehensive analysis regarding treatment persistence and adherence rates for the Greek territory.

Methods

This was a retrospective cohort study of patients initiating anti-fibrotic treatment during the period 2019-2023, utilizing data extracted from the National Electronic Prescription Database. Treatment persistence was defined as the duration from the date of the first prescription to the end of follow-up, death, or switching to another agent. Adherence was estimated based on the Medication Possession Ratio (MPR) metric.

Results

Overall, 2112 patients were analyzed. The majority were naive, male patients with a d

SUBMITTER: Kourlaba G 

PROVIDER: S-EPMC12821729 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature