Association of different serum creatinine trajectories with 28-day mortality in patients with acute kidney injury on chronic kidney disease: based on the MIMIC-IV database.

ABSTRACT:

Background

To evaluate the relationship between short-term longitudinal serum creatinine (Scr) trajectories and 28-day mortality in patients with acute kidney injury (AKI) on chronic kidney disease (CKD).

Methods

The data sources of this study were the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Group-Based Trajectory Modeling was used to classify the trajectories of Scr indices within 96 h after Intensive Care Unit admission. Kaplan-Meier survival curves were used to analyze the 28-day survival probabilities of patients with different Scr trajectories. Multivariate Cox proportional hazards models were applied to explore the association between different Scr trajectories and 28-day mortality. Receiver operating characteristic curves were employed to a

SUBMITTER: Ying J 

PROVIDER: S-EPMC12821818 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature