Genetic Landscape of Oral Cavity Squamous Cell Carcinoma.

ABSTRACT:

Objective

The association, if any, between gene mutations, pathologic features of squamous cell carcinoma of the head and neck, and patient prognosis is unknown. This study investigates the association between common gene mutations in oral cavity squamous cell carcinoma, pathologic features of malignancy, and patient survival.

Study design

Retrospective database review.

Setting

US hospitals.

Methods

The cBioPortal for Cancer Genomics database was queried for oral cavity squamous cell carcinoma patient data. Statistical analyses were conducted using IBM SPSS v29.

Results

Of the 423 patients included, the majority were male (66.6%), white (89.3%), and current/former smokers (74.1%). Tumor protein p53 (TP53), titin (TTN), and FAT atypical cadherin 1 (FAT1)

SUBMITTER: Celidonio J 

PROVIDER: S-EPMC12821888 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature