Myocardial interstitial fibrosis and subclinical left ventricular systolic dysfunction in type 2 diabetes mellitus patients with obesity: a 3.0 T MRI study.

ABSTRACT:

Background

Patients with type 2 diabetes mellitus (T2DM) who are obese have increased risk of cardiovascular events. This study aimed to investigate the impact of obesity on myocardial interstitial fibrosis and its association with subclinical left ventricular (LV) systolic dysfunction in patients with T2DM.

Methods

Eighty-one T2DM patients without obesity, 48 patients with obesity and 40 matched lean healthy controls were prospectively recruited and underwent cardiac magnetic resonance imaging. Extracellular volume (ECV), 3-D feature tracking strain including LV radial (GRS), circumferential (GCS) and longitudinal (GLS) peak strains were evaluated from T1 mapping and cine images, and compared among the groups.

Results

Compared with controls, the LV GRS and GLS were s

SUBMITTER: Li XM 

PROVIDER: S-EPMC12821896 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature