Proteomics analysis of aqueous and vitreous humor in uveitis: a systematic literature review.

ABSTRACT:

Purpose

Uveitis is an inflammatory ocular disease with diverse etiologies and pathogeneses. It potentially leads to significant visual impairment and socioeconomic burden. Proteomic analysis can provide insights into protein-driven mechanisms that may improve diagnosis, monitor disease progression, and identify therapeutic targets. Here, we summarize the proteomic results from studies investigating the aqueous and vitreous humor in eyes with uveitis versus non-inflammatory controls.

Methods

A comprehensive search of 15 databases was conducted on January 26, 2024. Studies were included if they performed proteomic analyses using mass spectrometry on aqueous or vitreous humor from uveitis patients. The selection, data extraction, and risk of bias assessment were performed indep

SUBMITTER: Reeg S 

PROVIDER: S-EPMC12821945 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature