Spatial-temporal dynamics of HZ prevalence among high-risk groups: a global multiregional cohort analysis since 1990.

ABSTRACT:

Background

Herpes zoster (HZ) is caused by the reactivation of the varicella-zoster virus (VZV). Individuals aged 50 years and older are at high risk due to immune aging. The Global Burden of Disease Study (GBD 2021) provides multidimensional data across regions and time series for analyzing HZ epidemiological characteristics in high-risk groups. However, studies on inequalities stratified by the Socio-demographic Index (SDI) and future trend predictions for these groups are still lacking.

Methods

Based on the GBD 2021 database, we extracted data on HZ incidence and disability-adjusted life years (DALYs) among individuals aged ≥ 50 years in 204 countries and regions from 1990 to 2021. We used the Age-Period-Cohort (APC) model, inequality indices (SII/CI), frontier analysis,

SUBMITTER: Yin Y 

PROVIDER: S-EPMC12821962 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature