Baicalin affects the progression of diabetic retinopathy through the RAGE/PXDN/PI3K/AKT pathway.

ABSTRACT:

Background

Diabetic retinopathy (DR) is the leading cause of blindness-related eye diseases in adults. The pathogenesis of DR is attributed to the excessive proliferation of microvessels, which leads to vitreous haemorrhage and retinal traction, thereby significantly damaging the patient's vision. In this study, we investigated the role and molecular mechanism of Peroxidasin (PXDN) and the active ingredient baicalin (BAI) of traditional Chinese medicine in regulating the senescence and pathological angiogenesis of human retinal microvascular endothelial cells (HRMECs) to identify the key genes and signalling pathways involved in the progression of DR.

Methods

In this study, key hub genes were screened using relevant datasets. The expression levels of PXDN, fibronectin (FN1),

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12821963 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature