Dataset Information
A pathway-informed mutual exclusivity framework to detect genetic interactions in pediatric cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Spinou A
PROVIDER: S-EPMC12822016 | biostudies-literature | 2025 Dec
REPOSITORIES: biostudies-literature
Publications
A pathway-informed mutual exclusivity framework to detect genetic interactions in pediatric cancer.
BMC medical genomics 20251212 1
BACKGROUND: The exponential increase of sequenced cancer genomes has enabled the in-silico study of genetic interactions in tumors across many cancer types—particularly synthetic lethality, where two gene alterations lead to cell death—and identify new candidate therapeutic targets. This rise is primarily present in adult cancer, while in-silico investigation of genetic interactions remains challenging in pediatric cancer especially in tumors of low incidence. Consequently, this underscores the ...[more]