Natural history parameters for enteric pathogens to inform modeling studies of diarrhea among children in low-resource settings: results from the MAL-ED longitudinal birth cohort.

ABSTRACT:

Background

Policy decisions may rely on mathematical modelling to predict intervention impacts. Information for key model parameters is limited for most enteric pathogens. To support informed modeling, we aimed to characterize incidence, severity, and duration for ten enteric pathogens - adenovirus 40/41, astrovirus, Campylobacter jejuni and C. coli, Cryptosporidium, norovirus GII, rotavirus, sapovirus, Shigella, heat-stable enterotoxin-producing enterotoxigenic Escherichia coli (ST-ETEC), and typical enteropathogenic E. coli (tEPEC) - among children aged 2 years or younger in South America, southeast Asia, and sub-Saharan Africa.

Methods

We analyzed stool specimens from MAL-ED, a multisite longitudinal birth cohort with active surveillance of children in South America, sout

SUBMITTER: Amin AB 

PROVIDER: S-EPMC12822059 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature