Association between systemic inflammation and risk of atrial fibrillation in cancer survivors: a population-based cohort study using UK biobank.

ABSTRACT:

Background

Cancer survivors (CSs) are at increased risk of atrial fibrillation (AF), potentially due to cancer-related inflammation and treatment effects. While inflammation has been implicated in both cancer and AF, the association between C-reactive protein (CRP) and AF risk in CSs remains unclear.

Methods

We analyzed data from 19,677 UK Biobank participants (mean age 60; 34.2% male) with a prior cancer diagnosis. Incident AF was evaluated using competing-risk Cox proportional hazards models, adjusting for sociodemographic, lifestyle, and clinical factors.

Results

Over a median follow-up of 10.4 years, 836 CSs (4.2%) developed AF. Competing risk analysis revealed that the significant association between elevated CRP (> 2 mg/L) and AF risk in CSs, observed in models

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12822089 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature