Self-healing PVA/PVP micelle-hydrogel composite system for potential phenytoin repositioning in wound healing.

ABSTRACT: The treatment of chronic and infected wounds remains a constant challenge; therefore, there is a need to develop multifunctional dressings that integrate mechanical resilience and antimicrobial activity via alternative drugs to prevent bacterial resistance. This study presents, for the first time, the design of self-healing hydrogels based on polyvinyl alcohol and polyvinylpyrrolidone, which were obtained by the freeze‒thaw method; these hydrogels enable physical crosslink formation without the use of toxic agents and serve as carriers for phenytoin repositioning, an antiepileptic drug recognized for its wound-healing properties. Phenytoin was incorporated via micelle-assisted solubilization, ensuring uniform distribution without damaging the hydrogel structure. The optimal formulation exh

SUBMITTER: Machado-Torres K 

PROVIDER: S-EPMC12822131 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature