Dataset Information
Effective serum concentration of high-dose methotrexate therapy for osteosarcoma with dose adjustment for pharmacokinetic parameters: a retrospective study.
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ABSTRACT:
SUBMITTER: Nagamine A
PROVIDER: S-EPMC12822136 | biostudies-literature | 2025 Dec
REPOSITORIES: biostudies-literature
Publications
Effective serum concentration of high-dose methotrexate therapy for osteosarcoma with dose adjustment for pharmacokinetic parameters: a retrospective study.
BMC cancer 20251210 1
BACKGROUND: In high-dose methotrexate (MTX) (HD-MTX) therapy, a dosage regimen utilizing the pharmacokinetic (PK) parameters of individual patients (PK method) has been developed to successfully reduce the intra- and inter-individual variability of serum MTX concentration. In this study, we evaluated the relationship between the therapeutic effect and serum MTX concentration in HD-MTX therapy performed under conditions in which the serum MTX concentration was precisely controlled using the PK me ...[more]