CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis.

ABSTRACT:

Background

Chronic endometritis (CE) is a persistent inflammatory condition associated with adverse pregnancy outcomes. Although impaired endometrial angiogenesis is thought to contribute to its pathogenesis, the underlying molecular mechanisms remain incompletely understood. This study aimed to investigate whether sphingolipid metabolism plays a role in the vascular dysfunction of CE patients.

Methods

Endometrial samples from control and CE patients were assessed for angiogenesis using immunohistochemistry. Sequencing data of endometrial tissues indicated dysregulation of sphingolipid metabolism in CE patients. ELISA revealed decreased levels of sphingosine-1-phosphate (S1P) in the endometrium of CE patients and in lipopolysaccharide (LPS)-treated human umbilical vein endot

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12822190 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature