Antigen B from Echinococcus granulosus regulates autophagy-mediated macrophage polarization to alleviate immune thrombocytopenia.

ABSTRACT:

Background

Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by a low platelet count (< 100 × 10⁹/L) induced by an autoimmune mechanism, which increases platelet clearing by macrophages. Antigen B (AgB) is a lipoprotein derived from Echinococcus granulosus larvae and has been observed to modulate host immunity. This study evaluated the mechanistic impact of AgB on macrophage polarization in the ITP mouse model.

Methods

This study analyzed blood samples acquired from pediatric patients with ITP and healthy controls. Furthermore, the levels of inflammatory cytokines in plasma, as well as macrophage surface markers and autophagy-related markers [microtubule-associated protein 1 light chain 3 (LC3) and sequestosome-1 (p62)] in peripheral bl

SUBMITTER: Song HC 

PROVIDER: S-EPMC12822193 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature