Discovery of globally rare CYP51 mutations associated with azole resistance in Iranian Zymoseptoria tritici isolates.

ABSTRACT:

Background

Septoria tritici blotch, caused by Zymoseptoria tritici, is a major wheat disease worldwide. Demethylation inhibitor (DMI) fungicides, which target the sterol 14α-demethylase enzyme encoded by the CYP51 gene, remain central to disease control. In Iran, propiconazole is extensively applied, raising concerns about the evolution of resistance. This study investigated potential CYP51-mediated resistance mechanisms in Iranian Z. tritici populations.

Results

Twenty-eight isolates collected from six major wheat-producing provinces were assessed for propiconazole sensitivity using a microdilution assay and were classified as sensitive, tolerant, or resistant based on IC₅₀ values. Sequencing of the CYP51 coding region in representative isolates revealed several amino acid

SUBMITTER: Esfehani A 

PROVIDER: S-EPMC12822247 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature