Successful VA-ECMO rescue of life-threatening cardiotoxicity following paclitaxel and cisplatin neoadjuvant chemotherapy for laryngeal cancer: a case report.

ABSTRACT:

Background

Neoadjuvant chemotherapy with paclitaxel and cisplatin (TP regimen) is a cornerstone of treatment for locally advanced laryngeal squamous cell carcinoma. While effective, this regimen can, in rare instances, induce multiple adverse events, including a life-threatening fulminant myocarditis. Characterized by sudden and severe cardiac inflammation leading to cardiogenic shock and arrhythmias, this complication carries a high mortality rate. Its non-specific initial symptoms often mimic more common conditions like acute coronary syndrome, posing significant diagnostic and therapeutic challenges for oncologists and critical care teams.

Case presentation

We describe the case of a 59-year-old male with laryngeal cancer who, after completing three cycles of neoadjuvant T

SUBMITTER: Qian Y 

PROVIDER: S-EPMC12822252 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature