Unraveling the connection between obesity, metabolic syndrome and osteoarthritis risk: a large-observational study.

ABSTRACT:

Background

The relationship between metabolic syndrome (MetS) and osteoarthritis (OA) remains debated, necessitating further exploration to clarify potential causal links.

Methods

This study included 271,019 participants from the UK Biobank and NHANES, and conducted Mendelian randomization (MR) analyses to determine the relationship between BMI, MetS, and OA. We used generalized linear modeling and restricted cubic spline plots to identify non-linear associations, as well as a mediation analysis of the possible mediating effect of MetS between BMI and OA. MR analyses were used to assess genetic causality, with sensitivity and subgroup analyses ensuring robustness.

Results

MetS was present in 27.3% of UK Biobank and 32.4% of NHANES participants, with OA prevalence at 1

SUBMITTER: Wang J 

PROVIDER: S-EPMC12822255 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature