Clinicopathological features of steroid-refractory immune-mediated hepatotoxicity induced by immune checkpoint inhibitors.

ABSTRACT:

Background

Mycophenolate mofetil (MMF) is a second-line agent for steroid-refractory immune checkpoint inhibitor-induced immune-mediated hepatotoxicity (IMH). However, the clinicopathologic characteristics and the efficacy and safety of MMF for steroid-refractory IMH are not fully understood.

Methods

This retrospective study enrolled 33 patients with pathologically diagnosed IMH by liver biopsy at Kyushu University Hospital between 2017 and 2023.

Results

Prednisolone (PSL) was administered as steroid monotherapy in 13 patients who were steroid-responsive or in combination with MMF in 10 patients who were steroid-refractory. Of the 10 steroid-refractory IMH cases, 9 eventually improved, but 1 was refractory to PSL + MMF. There were no adverse events related to MMF. Pat

SUBMITTER: Hioki T 

PROVIDER: S-EPMC12822274 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature