Curcumin induces ferroptosis in hepatocellular carcinoma by regulating the P62-KEAP1-NRF2-signaling pathway.

ABSTRACT:

Context

Hepatocellular carcinoma (HCC) remains a major global health challenge, with limited treatment options owing to chemotherapy resistance and severe systemic toxicity. Curcumin demonstrates broad-spectrum antitumor activity against HCC and various other malignancies. Ferroptosis, a regulated form of cell death driven by iron overload, glutathione depletion, and lipid peroxidation, has recently gained attention as a potential therapeutic strategy in cancer treatment. Among the regulatory networks of ferroptosis, the P62-KEAP1-NRF2-signaling pathway plays a pivotal role.

Objective

To assess whether curcumin induces ferroptosis in HCC cells through modulation of the P62-KEAP1-NRF2-signaling pathway.

Materials and methods

A Hepa1-6 xenograft mouse model was develope

SUBMITTER: Deng J 

PROVIDER: S-EPMC12822296 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature