Anticoagulation versus no anticoagulation after intracranial hemorrhage in patients with atrial fibrillation: an updated systematic review and meta-analysis.

ABSTRACT:

Background

Patients with atrial fibrillation (AF) and prior intracranial hemorrhage (ICH) present a therapeutic dilemma, where stroke prevention benefits of anticoagulation must be weighed against recurrent hemorrhage risks. Existing evidence remains inconclusive due to limited sample sizes. This updated meta-analysis synthesizes data from recent randomized controlled trials (RCTs) to determine whether anticoagulation provides net clinical benefit in this population.

Methods

We searched PubMed, Embase, and ClinicalTrials.gov until May 2025 for RCTs comparing anticoagulation versus no anticoagulation in AF patients with prior ICH. The primary efficacy and safety outcomes were ischemic stroke and recurrent ICH, respectively, with secondary outcomes of major adverse ischemic ev

SUBMITTER: Babaei M 

PROVIDER: S-EPMC12822325 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature