Associations of CCAT2 gene polymorphisms with neuroblastoma susceptibility in children from Jiangsu province.

ABSTRACT:

Background

The CCAT2 gene is associated with carcinogenesis, but its effect on neuroblastoma, the most common extracranial tumor in children, remains unclear.

Methods

We conducted a case-control study involving 402 children with neuroblastoma and 473 children without neuroblastoma. TaqMan genotyping of two CCAT2 polymorphisms (rs3843549 A > G and rs6983267 T > G) was conducted for all participants. Correlations were analyzed by calculating the odds ratio (OR) and 95% confidence interval (CI). Furthermore, we performed stratified analyses for both polymorphisms to evaluate their associations more comprehensively.

Results

We performed a statistical analysis employing three distinct genetic models to evaluate the rs3843549 A > G polymorphism and the rs6983267 T > G polym

SUBMITTER: Chen S 

PROVIDER: S-EPMC12822346 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature