Population genomic analyses reveal population structure and major hubs of invasive Anopheles stephensi in the Horn of Africa.

ABSTRACT: Anopheles stephensi invasion in the Horn of Africa (HoA) poses a substantial risk of increased malaria disease burden in the region. An understanding of the history of introduction(s), establishment(s) and potential A. stephensi sources in the HoA is needed to predict future expansions and establish where they may be effectively controlled. To this end, we take a landscape genomic approach to assess A. stephensi origins and spread throughout the HoA, information essential for vector control. Specifically, we assayed 2070 genome-wide single nucleotide polymorphisms across 214 samples spanning 13 populations of A. stephensi from Ethiopia and Somaliland collected in 2018 and 2020, respectively. Principal component and genetic ancestry analyses revealed clustering that followed an isolation-by

SUBMITTER: Samake JN 

PROVIDER: S-EPMC12822364 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature