Skin Biopsy for Phosphorylated α-Synuclein in Mild Cognitive Impairment or Dementia Due to Lewy Body Disease in a Convenience Cohort from a Subspecialty Behavioral Neurology Practice.

ABSTRACT:

Background

Immunohistochemically detected phosphorylated α-synuclein (p-α-syn) in cutaneous nerves has been found in >95% of patients meeting consensus criteria for dementia with Lewy bodies (DLB); however, its performance in prodromal stages (mild cognitive impairment-Lewy body [MCI-LB]) and clinical practice is unknown.

Objective

We evaluated skin biopsy for p-α-syn in a convenience cohort of patients with suspected MCI-LB or DLB in a tertiary care setting.

Methods

53 patients underwent commercially available skin biopsy for skin nerve p-α-syn as part of a clinical evaluation for suspected MCI-LB/DLB. Consensus MCI-LB/DLB criteria blinded to skin biopsy result were applied through retrospective chart review; those not definitively meeting criteria were considered qu

SUBMITTER: Rigby MJ 

PROVIDER: S-EPMC12822369 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature