Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk.

ABSTRACT: As the global production of bisphenol analogs (BPs) surges to replace regulated bisphenol A (BPA), their pervasive environmental presence and uncharacterized breast cancer risk raise critical public health concerns. Herein, the environmental risks of BPs are deciphered by linking their structural affinity for the progesterone receptor (PR), a master regulator of breast cancer, to oncogenic outcomes across experimental tiers. Molecular simulations reveal that environmental BPAF and BPB exhibited stronger binding to the PR-ligand binding domain (LBD) than BPA. Chemical assays confirm persistent PR-LBD structural changes after BPs exposure, mimicking endocrine disruption patterns. The cellular thermal shift assay also confirms the interaction between the PR and BPs. In vitro, BPAF and BPF boo

SUBMITTER: Ji X 

PROVIDER: S-EPMC12822391 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature