Payload-Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure-Function Relationships.

ABSTRACT: Polymeric carriers are gaining increasing attention for the delivery of a range of clinically relevant nucleic acid (NA) payloads, due to their efficacy, safety, and modular chemistry. While the requirements for an "optimal" carrier depend strongly on the NA payload, research has largely centered on carrier properties rather than the unique needs of the payload. Therefore, in this review, a novel perspective inspired by protein structural organization is introduced to explore structure-function relationships of polymeric carrier systems, highlighting the diverse requirements of different NA payloads. To gain deeper mechanistic insights, the complicated polymer/NA delivery systems are deconvoluted into four hierarchical levels, including molecular composition, structural features, complexat

SUBMITTER: Moradian H 

PROVIDER: S-EPMC12822472 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature