Single-cell RNA sequencing reveals genes relevant to periodontal therapy and periodontitis.

ABSTRACT: Periodontal therapy leverages intercellular and intertissue interactions between epithelium and stroma, which mediate healing and regeneration. Importantly, grafting stroma from different regions elicits different healing responses: transplantation of gingival stroma can convert alveolar mucosa into keratinized gingiva, and vice versa. This striking clinical observation suggests that the stromal tissues of oral mucosa and gingiva provide distinct instructional signals. Our aims were to investigate the molecular differences between mucosa and gingiva and the impact of periodontal infection on intertissue interactions. We used human single-cell RNA-sequencing (RNA-seq) data to compare gene expression patterns and intercellular interactions of: 1) adult oral mucosa and gingiva and 2

SUBMITTER: Sekiguchi R 

PROVIDER: S-EPMC12822488 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature