Rapid Glass-Substrate Digital Light 3D Printing Enables Anatomically Accurate Stroke Patient-Specific Carotid Artery-on-Chips for Personalized Thrombosis Investigation.

ABSTRACT: Translating patient-specific vascular geometries into functional microfluidic devices remains challenging due to fabrication limitations and lengthy processing times. Here, an ultrafast microfabrication platform is introduced using glass-substrate digital light processing 3D printing for creating patient-specific carotid artery-on-a-chip devices. The optimized protocol employs treated glass slides as printing substrates and custom-designed mechanical clamping, reducing manufacturing time from over 10 h to under 2 h with ≈100% success rate. The system accurately reproduces complex anatomical features from CT angiography data of stroke patients, including stenoses, bifurcations, and ulcerations that conventional reconstruction methods often miss. Computational fluid dynamics validation confi

SUBMITTER: Zhao YC 

PROVIDER: S-EPMC12822522 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature