Optoacoustic-Guided Magnetic Microrobot Platform for Precision Drug Delivery.

ABSTRACT: Precision drug delivery remains a significant challenge due to limitations in drug loading, targeted release, precise navigation, and real-time monitoring. Here, the study reports a magnetic microrobot platform (MMP) that integrates high-capacity drug loading, magnetically actuated collective navigation, controlled drug release, and real-time 3D optoacoustic imaging in a single system. The MMP exploits synergistic advantages by embedding hard-magnetic FePt nanoparticles in a degradable ZIF-8 shell, achieving a drug loading efficiency of ≈93.9% and enabling precise release in response to pH changes and radiofrequency-induced heating. Reconfigurable swarm behavior strategies significantly enhance the navigation efficiency of microrobots against physiological blood flows within complex cerebr

SUBMITTER: Wang F 

PROVIDER: S-EPMC12822537 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature