Impact of Artificial Intelligence for Detection of Precancerous Colonic Lesions in a Fecal Immunochemical Blood Test-Based Organized Screening Program in Italy: A Randomized Control Trial.

ABSTRACT:

Background

The fecal immunochemical test (FIT) is widely implemented as a first-line tool in organized colorectal cancer (CRC) screening programs, including Italy. Following a positive FIT, colonoscopy is recommended. Computer-aided detection (CADe) systems have the potential to enhance adenoma detection, particularly in FIT-positive populations where identifying advanced adenomas is critical for cancer prevention. This study evaluated the diagnostic performance of CADe-assisted colonoscopy versus standard colonoscopy (SC) in a FIT-based screening cohort.

Methods

In this multicenter, randomized controlled trial, patients with a positive FIT result were randomized to undergo either CADe-assisted or standard colonoscopy. The primary endpoint was the advanced adenoma detection

SUBMITTER: Spada C 

PROVIDER: S-EPMC12822568 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature