Yixiao Formula Suppresses Myocardial Fibrosis Through UpregulatingmiR-133a and Downregulating TGF-<i>β</i>/Smads Signal Molecules.

ABSTRACT:

Background

Yixiao formula (YXF), a traditional Chinese herbal medicine, has demonstrated clinical efficacy in alleviating symptoms of diabetic cardiomyopathy (DCM). The therapeutic mechanism underlying YXF's effects on DCM remains poorly understood. Myocardial fibrosis is a key pathogenic mechanism in DCM, and previous studies have indicated that miR-133a may be involved in its progression. Given that the TGF-β/Smads signaling pathway is a well-established mediator of myocardial fibrosis, investigating the mechanistic role of YXF through miR-133a and the TGF-β/Smads pathway warrants further exploration.

Objective

The main objective of this study is to investigate the potential contribution of the TGF-β/Smads pathway to the effects of YXF, as well as the

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC12822571 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature