Tuberculous meningitis alters the proteomic landscape of brain-derived extracellular vesicles.

ABSTRACT: Tuberculous meningitis (TB meningitis), the deadliest form of Mycobacterium tuberculosis infection, leads to mortality and severe neurological disability despite standard therapy. Brain injury and microglial activation are major determinants of outcome, yet the mechanisms linking infection, inflammation and neuronal injury remain poorly understood. Extracellular vesicles (EVs), key mediators of cell-to-cell communication, have been investigated in pulmonary TB but their role in TB meningitis remains unexplored. We used our young rabbit model of TB meningitis to isolate pure, intact EVs from brain tissue (i.e., brain-derived EVs) from infected and uninfected rabbits and used nanoflow cytometry, transmission electron microscopy and protein quantification to characterize the EVs. Compa

SUBMITTER: Rodriguez BV 

PROVIDER: S-EPMC12822729 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature