<i>Tert</i> Deletion Impairs Circadian Regulation of Blood Pressure in Male Spontaneously Hypertensive Rats.

ABSTRACT:

Background

Deletion of the Tert gene leads to telomere shortening, which is associated with aging and age-related cardiovascular disease, but its effects on circadian regulation of blood pressure have not yet been investigated. To fill this gap, we developed a rat model with genetic deletion of the Tert gene on a spontaneously hypertensive rat-Tert^-/- background, in which telomeres were shortened in the F3 generation.

Methods

We analyzed the effects of Tert deletion on locomotor activity, oxidative stress, telemetrically measured parameters of the cardiovascular system, and the expression of clock genes in various tissues.

Results

Male spontaneously hypertensive rat-Tert^-/- showed a reduced physical fitness, whi

SUBMITTER: Semenovykh K 

PROVIDER: S-EPMC12822765 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature