Neurobiological correlates of longitudinal grey matter volume changes in preclinical Alzheimer's disease.

ABSTRACT:

Background

Structural brain changes during the earliest asymptomatic stages of Alzheimer's disease (AD) remain poorly understood. Previous research in preclinical AD shows heterogeneous findings, reporting both subtle neuronal loss and paradoxical increases in grey matter (GM) volume. This study applies an extensive cerebrospinal fluid (CSF) biomarker panel to better understand the biological processes underlying longitudinal GM changes in cognitively unimpaired (CU) adults, spanning the amyloid/tau (AT) continuum.

Methods

We analysed data from 627 CU individuals from three longitudinal cohorts (ALFA+, Wisconsin ADRC, WRAP), with repeated MRI (3.5±0.9 years) and baseline CSF biomarkers from the NeuroToolKit panel (Roche Diagnostics). Using non-negative matrix factorization,

SUBMITTER: Pelkmans W 

PROVIDER: S-EPMC12822790 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature