The impact of delayed evacuation on the quality of human fetal tissue.

ABSTRACT:

Background

Agents such as digoxin and potassium chloride are frequently administered to arrest fetal circulation prior to termination procedures. Although this practice is common, the impact of delayed evacuation on human fetal tissue quality has not been systematically assessed. High-quality tissue is essential for accurate diagnosis of fetal abnormalities and for biomedical research.

Objective

To evaluate the effects of induced fetal demise and delayed evacuation on human fetal tissue quality across multiple organ systems, and to determine whether digoxin independently contributes to tissue degradation.

Study design

Tissue was collected from second-trimester dilation and evacuation procedures performed either after induced demise with digoxin or potassium chloride f

SUBMITTER: Otaibi Y 

PROVIDER: S-EPMC12822946 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature